反应详情

1-Benzyl-3-ethyl-3-methyl-4-piperidinone (4.2 g, 18.18 mmol) was added to the stirred solution cyclopropylamine (6.5 g, 115 mmol) in methanol (100 ml) and stirred for 6 hr. Sodium cyanoborohydride (1.14 g, 18.18 mmol) was added to it and reaction mixture was stirred for 15 hr. The reaction mixture was concentrated to dryness, triturated with water, extracted with chloroform, dried (Na2SO4) and concentrated to furnish crude 1-benzyl-4-cyclopropylamino-3-ethyl-3-methylpiperidine. Yield 4 g (88%), C18H28N2, m/z 273 (M+1).

1. stirringwas stirred for 15 hr
2. concentrationThe reaction mixture was concentrated to dryness
3. customtriturated with water
4. extractionextracted with chloroform
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated