HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Oxa-8-azaspiro[4.5]decan-4-ol;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate | HCID 69148346 | — |
| Product | 2-Oxa-8-azaspiro[4.5]decan-4-ol;hydrochloride | HCID 21955363 | 77% |
Reaction Steps
4-Hydroxy-2-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester (Description 7; 0.86 g, 3.3 mmol) was stirred overnight in 2M ethereal hydrogen chloride. The mixture was filtered and the solid dried to give the title compound (0.5 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393858B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-71745428221841cf9c83193506c93059 |
| Source note | uspto-grants-2008_07 |