Hydrochloric Acid → 2-Oxa-8-azaspiro[4.5]decan-4-ol;hydrochloride

HRID 746998Notes

Reaction equation

HRID 746998 reaction equation
CC(OC([N:8]1[CH2:18][CH2:17][C:11]2([CH2:15][O:14][CH2:13][CH:12]2[OH:16])[CH2:10][CH2:9]1)=O)(C)C.[ClH:19]>>[ClH:19].[CH2:15]1[C:11]2([CH2:17][CH2:18][NH:8][CH2:9][CH2:10]2)[CH:12]([OH:16])[CH2:13][O:14]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69148346Tert-butyl 4-hydroxy-2-oxa-8-azaspiro[4.5]decane-8-carboxylate

Product 1

HCID 219553632-Oxa-8-azaspiro[4.5]decan-4-ol;hydrochlorideYield 77%

Procedure

4-Hydroxy-2-oxa-8-aza-spiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester (Description 7; 0.86 g, 3.3 mmol) was stirred overnight in 2M ethereal hydrogen chloride. The mixture was filtered and the solid dried to give the title compound (0.5 g, 77%).

Workup

  1. filtrationThe mixture was filtered
  2. customthe solid dried

Sources & evidence

ORD record
ord-71745428221841cf9c83193506c93059
Source dataset
uspto-grants-2008_07
Patent number
US07393858B2

Reaction notes

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