Hydrochloric Acid → 1-Oxa-8-azaspiro(4.5)decane hydrochloride

HRID 747007Notes

Reaction equation

HRID 747007 reaction equation
[ClH:1].O1[C:6]2([CH2:11][CH2:10][CH:9]([C:12]([O:14]C(C)(C)C)=O)CC2)[CH2:5][NH:4][CH2:3]1.[CH3:19]O>>[ClH:1].[O:14]1[C:11]2([CH2:19][CH2:3][NH:4][CH2:5][CH2:6]2)[CH2:10][CH2:9][CH2:12]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 692216311,1-Dimethylethyl 1-oxa-3-azaspiro[4.5]decane-8-carboxylate

Product 1

HCID 219349811-Oxa-8-azaspiro(4.5)decane hydrochlorideYield 98%

Procedure

Methanolic hydrogen chloride (3M, 20 ml) was added over 10 minutes to a stirred, cooled (0° C.) solution of 1,1-dimethylethyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iv) above, 3.18 g, 13.2 mmol) in methanol (10 ml) and the mixture was stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure to give the title compound (2.29 g, 98%).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-2a85b5a462b848fc85e65a26dde730bf
Source dataset
uspto-grants-2008_07
Patent number
US07393858B2

Reaction notes

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