Trifluoroacetic acid → HCID 69147864, compound

HRID 747016Notes

Reaction equation

HRID 747016 reaction equation
[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]2)[O:5][CH2:4][CH2:3]1.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[O:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 697044001-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 4-hydroxy-, 1,1-diMethylethyl ester

Product 1

HCID 69147864HCID 69147864, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iii) above; 300 mg) was dissolved in dichloromethane and trifluoroacetic acid (2 mL) was added. The solution was stirred for 2 h and was concentrated in vacuo to afford the product as a colorless oil.

Workup

  1. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-16bd56e72b6c4f89907764f89e395b12
Source dataset
uspto-grants-2008_07
Patent number
US07393858B2

Reaction notes

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