HCID 69148474, compound → 4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane

HRID 747020Notes

Reaction equation

HRID 747020 reaction equation
[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][N:9](C(OCC3C=CC=CC=3)=O)[CH2:8][CH2:7]2)[CH2:5][O:4][C:3]1([CH3:23])[CH3:22]>CO.[Pd]>[OH:1][CH:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][O:4][C:3]1([CH3:23])[CH3:22]

Participants

4

Reactant 1

HCID 69148474HCID 69148474, compound

Product 1

HCID 691473354-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl 4-hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iii) above; 180 mg) was dissolved in methanol and palladium on carbon (5%) was added. The mixture was hydrogenated at atmospheric pressure for 30 min. The catalyst was removed by filtration through Hyflo™ and the solvent was evaporated in vacuo to afford the product as a white solid.

Workup

  1. customThe catalyst was removed by filtration through Hyflo™
  2. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-500f7eb397384da2983159cada5dfeec
Source dataset
uspto-grants-2008_07
Patent number
US07393858B2

Reaction notes

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