HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 69148474, compound → 4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 69148474 | HCID 69148474 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane | HCID 69147335 | — |
Reaction Steps
Benzyl 4-hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane-8-carboxylate (from step (iii) above; 180 mg) was dissolved in methanol and palladium on carbon (5%) was added. The mixture was hydrogenated at atmospheric pressure for 30 min. The catalyst was removed by filtration through Hyflo™ and the solvent was evaporated in vacuo to afford the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393858B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-500f7eb397384da2983159cada5dfeec |
| Source note | uspto-grants-2008_07 |