HRID747034

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID45083201

1-Oxa-8-azaspiro[4.5]decan-4-ol

C8H15NO2

结构：C[C@@H](O[C@H]1OCC[C@@H](C=O)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID86601738

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](O[C@H]1OCC[C@@H](CN2CCC3(CC2)OCCC3O)[C@@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID86606928

未命名化合物

PROCEDURE

实验过程

This product was prepared according to the procedure described in Example 2 using (2R,3R,4R)-2-[(1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-phenyl-tetrahydropyran-4-carbaldehyde (WO 0056727) and 4-hydroxy-1-oxa-8-azaspiro[4.5]decane (Description 20).

WORKUP

后处理

customThis product was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d472804dfb9f410999f7886349a36f4c
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07393858B2
来源说明: uspto-grants-2008_07

反应 SMILES

[F:1][C:2]([F:31])([F:30])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@@H:16]2[C@@H:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C@H:20]([CH:28]=O)[CH2:19][CH2:18][O:17]2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[OH:32][CH:33]1[C:37]2([CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[O:36][CH2:35][CH2:34]1>>[F:12][C:9]([F:11])([F:10])[C:7]1[CH:6]=[C:5]([C@H:13]([O:15][C@@H:16]2[C@@H:21]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[C@H:20]([CH2:28][N:40]3[CH2:41][CH2:42][C:37]4([O:36][CH2:35][CH2:34][CH:33]4[OH:32])[CH2:38][CH2:39]3)[CH2:19][CH2:18][O:17]2)[CH3:14])[CH:4]=[C:3]([C:2]([F:30])([F:31])[F:1])[CH:8]=1