HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Oxa-8-azaspiro[4.5]decan-4-ol → (4RS)-8-[(2R,3R,4R)-2-[(1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-phenyl-tetrahydropyran-4-yl]methyl-1-oxa-8-azaspiro[4.5]decan-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Oxa-8-azaspiro[4.5]decan-4-ol | HCID 45083201 | — |
| Reactant | (2R,3R,4R)-2-[(1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-phenyl-tetrahydropyran-4-carbaldehyde | HCID 86601738 | — |
| Product | (4RS)-8-[(2R,3R,4R)-2-[(1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-phenyl-tetrahydropyran-4-yl]methyl-1-oxa-8-azaspiro[4.5]decan-4-ol | HCID 86606928 | — |
Reaction Steps
This product was prepared according to the procedure described in Example 2 using (2R,3R,4R)-2-[(1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-phenyl-tetrahydropyran-4-carbaldehyde (WO 0056727) and 4-hydroxy-1-oxa-8-azaspiro[4.5]decane (Description 20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393858B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-d472804dfb9f410999f7886349a36f4c |
| Source note | uspto-grants-2008_07 |