HRID747035

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69147335

未命名化合物

结构：C[C@@H](O[C@H]1OCC[C@@H](C=O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID86601740

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](O[C@H]1OCC[C@@H](CN2CCC3(CC2)COC(C)(C)C3O)[C@@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

HCID86606929

未命名化合物

PROCEDURE

实验过程

This product was prepared according to the procedure described in Example 6 using (2R,3R,4R)-2-[(1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-tetrahydropyran-4-carbaldehyde (Description 11) and 4-hydroxy-3,3-dimethyl-2-oxa-8-azaspiro[4.5]decane (Description 21).

WORKUP

后处理

customThis product was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-846462ac8fc04eee9291ebf90f4f1ded
来源数据集: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07393858B2
来源说明: uspto-grants-2008_07

反应 SMILES

[F:1][C:2]([F:32])([F:31])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@@H:16]2[C@@H:21]([C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)[C@H:20]([CH:29]=O)[CH2:19][CH2:18][O:17]2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[OH:33][CH:34]1[C:38]2([CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[CH2:37][O:36][C:35]1([CH3:45])[CH3:44]>>[F:32][C:2]([F:1])([F:31])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@@H:16]2[C@@H:21]([C:22]3[CH:23]=[CH:24][C:25]([F:28])=[CH:26][CH:27]=3)[C@H:20]([CH2:29][N:41]3[CH2:42][CH2:43][C:38]4([CH2:37][O:36][C:35]([CH3:45])([CH3:44])[CH:34]4[OH:33])[CH2:39][CH2:40]3)[CH2:19][CH2:18][O:17]2)[CH3:14])[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1