HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 7-Bromomethyl-6-chlorochroman-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-Chloro-7-Methylchromanone | HCID 5022474 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 7-Bromomethyl-6-chlorochroman-4-one | HCID 69077375 | — |
Reaction Steps
A mixture of 6-chloro-7-methyl-chroman-4-one (20 g, 101.71 mmol), NBS (19.9 g, 111.88 mmol), and AIBN (4.17 g, 25.43 mmol) in anhydrous CCl4 (300 mL) was heated at reflux in 24 h. The mixture was cooled, filtered the solid. The filtrate was concentrated and used in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07393852B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-98a6690227fa40ce860c57bb25e4eee3 |
| Source note | uspto-grants-2008_07 |