2-Hydrazinoethanol → 883997-72-6

HRID 747054Notes

Reaction equation

HRID 747054 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][NH2:5].CN([CH:9]=[C:10]1[C:15](=[O:16])[CH2:14][CH2:13][CH2:12][C:11]1=O)C>CO>[OH:1][CH2:2][CH2:3][N:4]1[C:11]2[CH2:12][CH2:13][CH2:14][C:15](=[O:16])[C:10]=2[CH:9]=[N:5]1

Participants

4

Reactant 2

HCID 80172-HydrazinoethanolHCID 3593532-[(Dimethylamino)methylidene]cyclohexane-1,3-dione

Product 1

HCID 59747921883997-72-6

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-hydroxyethyl hydrazine (1.36 mL, 20 mmol) was slowly added to an ice-cooled solution of 2-((dimethylamino)methylene)cyclohexane-1,3-dione (3.34 g) in methanol (50 mL). After stirring at room temperature for 20 min, the solvent was evaporated. Flash chromatography (SiO2, EtOAc/MeOH=100:5 to 100:7 to 100:10) gave the title compound as a white solid. B. Preparation of 1-(2-(tert-butyldimethylsilyloxy)ethyl)-6,7-dihydro-1H-indazol-4(5H)-one.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-a3b7b953f89e4b18b41ae96a4fb78b3a
Source dataset
uspto-grants-2008_07
Patent number
US07393852B2

Reaction notes

Loading…