反应详情

4-Hydroxybenzoic acid (3.00 g, 2.17×10−2 mol) was dissolved in a mixture of ethanol (15 cm3) and potassium hydroxide (3.22 g, 5.64×10−2 mol) in water (5 cm3). The solution was then heated gently and stirred before 1-bromo-2-methoxyethane (3.32 g, 2.39×10−2mol) and potassium iodide (0.01 g, 6.02×10−5 mol) was added slowly. The resulting reaction mixture was then refluxed (15 hrs) and the solvent evaporated and the resulting solid residue dissolved in water (50 cm3). The solution was washed with ether and then made strongly acidic with hydrochloric acid. The resulting precipitate was isolated and recrystallised from ethanol. Yield 1.36 g (32%).

1. temperatureThe solution was then heated gently
2. additionwas added slowly
3. customThe resulting reaction mixture
4. temperaturewas then refluxed (15 hrs)
5. customthe solvent evaporated
6. dissolutionthe resulting solid residue dissolved in water (50 cm3)
7. washThe solution was washed with ether
8. customThe resulting precipitate was isolated
9. customrecrystallised from ethanol