7-Amino-4-methyl-2-quinolinone → HCID 178429270, compound

HRID 747118Notes

Reaction equation

HRID 747118 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[CH:4][N:3]=1.[CH3:18][C:19]1[C:25]2[CH:26]=[CH:27][C:28]([NH2:30])=[CH:29][C:24]=2[NH:23][C:21](=[O:22])[CH:20]=1>>[ClH:1].[CH3:18][C:19]1[C:25]2[C:24](=[CH:29][C:28]([NH:30][C:2]3[CH:7]=[C:6]([C:8]4[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=4)[N:5]=[CH:4][N:3]=3)=[CH:27][CH:26]=2)[N:23]=[C:21]([OH:22])[CH:20]=1

Participants

3

Reactant 2

HCID 882777-Amino-4-methyl-2-quinolinoneHCID 167478374-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine

Product 1

HCID 178429270HCID 178429270, compound

Procedure

Analogous to the procedure used to prepare Example 5(b), 4-chloro-6-(4-trifluoromethylphenyl)pyrimidine, Example 5(a), (150 mg, 0.58 mmol) and carbostyril 124 (50 mg, 0.29 mmol, Aldrich) afforded, after recrystallization from MeOH, the title product as bright-yellow crystals. MP: 373° C. (with decomposition). MS (ESI, pos. ion) m/z: 397 (M+1).

Workup

  1. customafforded
  2. customafter recrystallization from MeOH

Sources & evidence

ORD record
ord-574c49fe495d4af8921101c7445bbd72
Source dataset
uspto-grants-2008_07
Patent number
US07396831B2

Reaction notes

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