反应详情

Analogous to the procedure used to prepare Example 5(b), 4-chloro-6-(4-trifluoromethylphenyl)pyrimidine, Example 5(a), (690 mg, 2.67 mmol) and 4-aminobenzimidazole (296 mg, 2.22 mmol, Astatech) afforded after purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2, the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 356 (M+1).

1. customafforded
2. customafter purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2