4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine → (1H-Benzoimidazol-4-yl)-[6-(4-trifluoromethylphenyl)pyrimidin-4-yl]amine

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Reaction Steps

Analogous to the procedure used to prepare Example 5(b), 4-chloro-6-(4-trifluoromethylphenyl)pyrimidine, Example 5(a), (690 mg, 2.67 mmol) and 4-aminobenzimidazole (296 mg, 2.22 mmol, Astatech) afforded after purification by silica gel chromatography with gradient from 1% to 10% solution of (2 M NH3 in MeOH) in CH2Cl2, the title compound as a yellow solid. MS (ESI, pos. ion.) m/z: 356 (M+1).

Provenance & Evidence