Trifluoroacetic acid → Quinolin-7-yl-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-pyrimidin-4-yl)-amine

HRID 747134Notes

Reaction equation

HRID 747134 reaction equation
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[C:18]([NH:20][C:21]3[CH:30]=[C:29]4[C:24]([CH:25]=[CH:26][CH:27]=[N:28]4)=[CH:23][CH:22]=3)[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:28]1[C:29]2[C:24](=[CH:23][CH:22]=[C:21]([NH:20][C:18]3[CH:19]=[C:14]([C:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=4)[N:15]=[CH:16][N:17]=3)[CH:30]=2)[CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 235772364-[6-(Quinolin-7-ylamino)-pyrimidin-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Product 1

HCID 22135542Quinolin-7-yl-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-pyrimidin-4-yl)-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

This compound could be prepared from 4-[6-(quinolin-7-ylamino)-pyrimidin-4-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester in the presence of TFA and CH2Cl2.

Sources & evidence

ORD record
ord-3972a30e0ed645a484c2e6166d4d52f6
Source dataset
uspto-grants-2008_07
Patent number
US07396831B2

Reaction notes

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