2-Acetylfuran → HCID 535936, compound

HRID 747148Notes

Reaction equation

HRID 747148 reaction equation
[C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:11][N:12]([CH3:14])[CH:13]=[CH:2][C:1]([C:4]1[O:5][CH:6]=[CH:7][CH:8]=1)=[O:3]

Participants

3

Reactant 2

HCID 145052-AcetylfuranHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 535936HCID 535936, compoundYield 97%

Conditions

Temperature
100 °C

Procedure

A mixture of 2-acetylfuran (25.0 g, 0.227 mol) and N,N-dimethylformamide dimethylacetal (40 ml) was stirred at 100° C. for 9 hours. After cooling as it was, the reaction mixture was concentrated. To the residue were added diethyl ether and hexane. The resulting solid was collected by filtration and washed with hexane, to give the title compound (36.5 g, 97%) as a brown solid.

Workup

  1. temperatureAfter cooling as it
  2. concentrationthe reaction mixture was concentrated
  3. additionTo the residue were added diethyl ether and hexane
  4. filtrationThe resulting solid was collected by filtration
  5. washwashed with hexane

Sources & evidence

ORD record
ord-f719234000f54031b9cac03a1799a13f
Source dataset
uspto-grants-2008_07
Patent number
US07396836B2

Reaction notes

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