Water → HCID 57435654, compound

HRID 747177Notes

Reaction equation

HRID 747177 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[C:9]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)=[N:10][C:11]([NH2:14])=[N:12][CH:13]=2)[CH:5]=[CH:4][N:3]=1.[OH2:20].[OH-].[Na+]>Cl>[NH2:14][C:11]1[N:10]=[C:9]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[C:8]([C:6]2[CH:5]=[CH:4][NH:3][C:2](=[O:20])[CH:7]=2)=[CH:13][N:12]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23020412HCID 23020412, compound

Product 1

HCID 57435654HCID 57435654, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

A suspension of 5-(2-fluoro-4-pyridyl)-4-(2-furyl)-2-pyrimidinylamine (3.00 g, 11.70 mmol) in concentrated hydrochloric acid (15 ml)-water (15 ml) was stirred at 100° C. for 2 hours. After cooling as it was, the reaction mixture was neutralized with a 5N aqueous sodium hydroxide solution. The resulting solid was collected by filtration, washed with water and dried at 60° C. for 22 hours, to give the title compound (2.19 g, 70%) as a pale brown solid.

Workup

  1. temperatureAfter cooling as it
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with water
  4. customdried at 60° C. for 22 hours

Sources & evidence

ORD record
ord-b3f5dc67f0794580bfea7b2211db1142
Source dataset
uspto-grants-2008_07
Patent number
US07396836B2

Reaction notes

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