反应详情

5-Azidomethyl-3-(5-bromo-thien-2-yl)-4,5-dihydro-isoxazole (500 mg, 1.74 mmol) and bicyclo[2.2.1]hepta-2,5-diene (1 ml) were combined with dioxane (2 ml) and subjected to microwave radiation in a Smith Personal Synthesizer for 900 seconds at 125° C. The reaction mixture was concentrated in vacuo and ethyl acetate (5 ml) was added. The precipitate was filtered and washed with ethyl acetate (2×5 ml) to give the desired product (234 mg).

1. customfor 900 seconds
2. customat 125° C
3. concentrationThe reaction mixture was concentrated in vacuo and ethyl acetate (5 ml)
4. additionwas added
5. filtrationThe precipitate was filtered
6. washwashed with ethyl acetate (2×5 ml)