Tetrabutylammonium Fluoride → HCID 59749421, compound

HRID 747234Notes

Reaction equation

HRID 747234 reaction equation
[Si]([O:8][CH2:9][C@@H:10]1[O:14][C:13](=[O:15])[N:12]([C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][C:25]([N:28]4[CH2:32][C@H:31]([CH2:33][N:34]5[CH:38]=[C:37]([CH3:39])[N:36]=[N:35]5)[O:30][C:29]4=[O:40])=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)[CH2:11]1)(C(C)(C)C)(C)C.[F-:41].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:41][C:23]1[CH:24]=[C:25]([N:28]2[CH2:32][C@H:31]([CH2:33][N:34]3[CH:38]=[C:37]([CH3:39])[N:36]=[N:35]3)[O:30][C:29]2=[O:40])[CH:26]=[CH:27][C:22]=1[C:19]1[CH:20]=[CH:21][C:16]([N:12]2[CH2:11][C@H:10]([CH2:9][OH:8])[O:14][C:13]2=[O:15])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 2724141Tetrabutylammonium FluorideHCID 59749477HCID 59749477, compound

Product 1

HCID 59749421HCID 59749421, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

(5R)-5-({[tert-Butyl(dimethyl)silyl]oxy}methyl)-3-(4′-{(5R)-5-[(4-methyl-1H-1,2,3-triazol-1-yl)methyl]-2-oxo-1,3-oxazolidin-3-yl}-1,1′-biphenyl-4-yl)-1,3-oxazolidin-2-one (0.016 g, 0.030 mM) was suspended in tetrahydrofuran (0.5 ml) and a 1N solution of tetrabutylammoniumfluoride in tetrahydrofuran (0.03 ml) was added. The reaction was stirred at room temperature for one hour. The cloudy suspension was concentrated as a white residue.

Workup

  1. concentrationThe cloudy suspension was concentrated as a white residue

Sources & evidence

ORD record
ord-45e9c96aa32642a9b557fe5b5c058475
Source dataset
uspto-grants-2008_07
Patent number
US07396847B2

Reaction notes

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