HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → N-(5-(4-Chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-yl)methyl-N-methylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Ethylamine | HCID 6341 | — |
| Reactant | 3-Butyn-2-amine, 2-methyl- | HCID 76319 | — |
| Reactant | (4-Chlorophenyl)methanesulfonyl chloride | HCID 227304 | — |
| Product | N-(5-(4-Chlorophenyl)-3,3-dimethyl-1,1-dioxo-2,3-dihydroisothiazol-4-yl)methyl-N-methylamine | HCID 17973783 | — |
Reaction Steps
The title compound was prepared from (4-chlorophenyl)methanesulfonyl chloride and 1,1-dimethylpropargylamine according to the procedure described for Intermediate 4 replacing ethylamine by methylamine in the last step. 1H-NMR (DMSO-d6) δ 7.72 (bs, 1 H), 7.53 (m, 4H), 3.33 (s, 2 H), 2.16 (s, 3 H), 1.45 (s, 6 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07396846B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-838454c507bb490a94cb7a1fef6d9629 |
| Source note | uspto-grants-2008_07 |