Diethyl (ethoxymethylene)malonate → HCID 59410120, compound

HRID 747490Notes

Reaction equation

HRID 747490 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][CH3:10])[NH2:5].C(O[CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17])C>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 5811103-Fluoro-4-methoxyaniline

Product 1

HCID 59410120HCID 59410120, compound

Procedure

A stirred mixture of 15.61 g of 3-fluoro-4-methoxyaniline and of 24.25 g of diethyl ethoxymethylenemalonate is brought to 100° C. for 2.5 hours. After cooling to ambient temperature and then evaporation to dryness at 50° C. under reduced pressure, 35 g of diethyl 2-[(3-fluoro-4-methoxyphenylamino)methylene]malonate are obtained, in the form of a beige solid which melts at 63° C.

Workup

  1. customevaporation to dryness at 50° C. under reduced pressure, 35 g of diethyl 2-[(3-fluoro-4-methoxyphenylamino)methylene]malonate
  2. customare obtained, in the form of a beige solid which melts at 63° C.

Sources & evidence

ORD record
ord-710780901e16400196cebd7a6899726e
Source dataset
uspto-grants-2008_07
Patent number
US07396934B2

Reaction notes

Loading…