Hydrochloric Acid → HCID 22350951, compound

HRID 747504Notes

Reaction equation

HRID 747504 reaction equation
[CH3:1][C:2]1[S:6][C:5](=[N:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]([CH2:14][CH2:15][CH2:16][NH:17]C(=O)OC(C)(C)C)[C:3]=1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.Cl>O1CCOCC1>[NH2:17][CH2:16][CH2:15][CH2:14][N:4]1[C:3]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:2]([CH3:1])[S:6][C:5]1=[N:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 22350995HCID 22350995, compound

Product 1

HCID 22350951HCID 22350951, compoundYield 115.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

t-Butyl 3-[5-methyl-4-phenyl-2-(phenylimino)thiazol-3(2H)-yl]propylcarbamate (370 mg) and a 4N solution of hydrogen chloride in dioxane (4 ml) were treated in a similar manner to in Example 9 (2) to give the title compound (327 mg) as hydrochloride.

Sources & evidence

ORD record
ord-d48d670f1b9143e582f5bacdf69ea9ec
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

Loading…