Hydrochloric Acid → HCID 22350964, compound

HRID 747505Notes

Reaction equation

HRID 747505 reaction equation
[C:1]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:6]=[CH:5][C:4]([C:7]2[N:8]([CH2:19][CH2:20][CH2:21][NH:22]C(=O)OC(C)(C)C)[C:9](=[N:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[S:10][CH:11]=2)=[CH:3][CH:2]=1.Cl.O>O1CCOCC1>[NH2:22][CH2:21][CH2:20][CH2:19][N:8]1[C:7]([C:4]2[CH:5]=[CH:6][C:1]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)=[CH:2][CH:3]=2)=[CH:11][S:10][C:9]1=[N:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 22351044HCID 22351044, compound

Product 1

HCID 22350964HCID 22350964, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of t-butyl 3-[4-(1,1′-biphenyl-4-yl)-2-(phenylimino)-thiazol-3(2H)-yl]propylcarbamate (233 mg) and a 4N solution of hydrogen chloride in dioxane (2 ml) was stirred at room temperature for one hour. To the reaction mixture was added water, and the mixture was washed with diethyl ether. The aqueous layer was basified with a saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with chloroform. The organic layer was washed with a saturated brine, and dried over sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (185 mg).

Workup

  1. washthe mixture was washed with diethyl ether
  2. extractionthe mixture was extracted with chloroform
  3. washThe organic layer was washed with a saturated brine
  4. dry with materialdried over sodium sulfate
  5. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-82e1a27f070745e783bca5a724dbaeca
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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