HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| Reactant | N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline | HCID 22350937 | — |
| Product | N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline | HCID 22350959 | 45% |
Reaction Steps
The compound (313 mg) obtained in Example 208 (2) and 4-chlorobenzyl bromide (216 mg) were treated in a similar manner to in Example 208 (3), (4) to give the title compound (152 mg) as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07396842B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-578497bad5c64efda0ce4912a782e260 |
| Source note | uspto-grants-2008_07 |