Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline

HRID 747510Notes

Reaction equation

HRID 747510 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:9]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:8][S:7][C:6]1=[N:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]([F:30])([F:29])[F:28])=[CH:22][CH:21]=1.[Cl:31]C1C=CC(CBr)=CC=1.Cl>>[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:9]([CH2:10][O:11][CH2:12][C:13]2[CH:14]=[CH:15][C:16]([Cl:31])=[CH:17][CH:18]=2)=[CH:8][S:7][C:6]1=[N:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][C:27]([F:29])([F:30])[F:28])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 22350937N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline2×

Product 1

HCID 22350959N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)anilineYield 45%

Procedure

The compound (313 mg) obtained in Example 208 (2) and 4-chlorobenzyl bromide (216 mg) were treated in a similar manner to in Example 208 (3), (4) to give the title compound (152 mg) as hydrochloride.

Sources & evidence

ORD record
ord-578497bad5c64efda0ce4912a782e260
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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