Hydrochloric Acid → HCID 22351011, compound

HRID 747512Notes

Reaction equation

HRID 747512 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:9]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:8][S:7][C:6]1=[N:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][N:21]=1.NCCCN1C(COCC2C=CC=CC=2)=CSC1=NC1C=CC(OC(F)(F)F)=CC=1.[ClH:58]>>[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:9]([CH2:10][O:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:58])=[CH:15][CH:14]=2)=[CH:8][S:7][C:6]1=[N:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][N:21]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 22350937N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)anilineHCID 22351036N-[3-(3-Aminopropyl)-4-[(benzyloxy)methyl]thiazol-2(3H)-ylidene]-5-methoxy-2-pyridinamine

Product 1

HCID 22351011HCID 22351011, compound

Procedure

The compound (276 mg) obtained in Example 210 (1) was treated in a similar manner to in Example 208 (3), (4) to give the title compound (92 mg) as hydrochloride.

Sources & evidence

ORD record
ord-da0de519927c456db9f30849dd9b2d4d
Source dataset
uspto-grants-2008_07
Patent number
US07396842B2

Reaction notes

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