Sodium Hydroxide → HCID 69117392, compound

Participants

Reaction Steps

53.8 g of crude methyl 2-fluoro-2-methyl-4-(methylsulfonyl)benzoate were initially charged in 500 ml of THF, and 10.5 g NaOH dissolved in 500 ml of H2O were added. The mixture was stirred at RT for 3 h, and most of the THF was then removed under reduced pressure. The residue was washed with diethyl ether and the aqueous phase was then acidified with 10% strength H2SO4. The precipitated crystals were filtered off with suction, washed with cold water and dried. This gave colorless crystals.

Provenance & Evidence