Sodium Hydroxide → HCID 69117392, compound

HRID 747540Notes

Reaction equation

HRID 747540 reaction equation
[F:1][C:2]1([CH3:16])[CH:11]=[C:10]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:9]=[CH:8][CH:3]1[C:4]([O:6]C)=[O:5].[OH-].[Na+]>C1COCC1.O>[F:1][C:2]1([CH3:16])[CH:11]=[C:10]([S:12]([CH3:15])(=[O:14])=[O:13])[CH:9]=[CH:8][CH:3]1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 69283954HCID 69283954, compound

Product 1

HCID 69117392HCID 69117392, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

53.8 g of crude methyl 2-fluoro-2-methyl-4-(methylsulfonyl)benzoate were initially charged in 500 ml of THF, and 10.5 g NaOH dissolved in 500 ml of H2O were added. The mixture was stirred at RT for 3 h, and most of the THF was then removed under reduced pressure. The residue was washed with diethyl ether and the aqueous phase was then acidified with 10% strength H2SO4. The precipitated crystals were filtered off with suction, washed with cold water and dried. This gave colorless crystals.

Workup

  1. additionwere added
  2. custommost of the THF was then removed under reduced pressure
  3. washThe residue was washed with diethyl ether
  4. filtrationThe precipitated crystals were filtered off with suction
  5. washwashed with cold water
  6. customdried

Sources & evidence

ORD record
ord-7d11387b0f9f48d3a2c5ea4bbcb5f27f
Source dataset
uspto-grants-2008_07
Patent number
US07396939B2

Reaction notes

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