5-(Methoxycarbonyl)thiophene-2-carboxylic acid → 5-[1-(5-Bromo-thiophen-2-yl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

HRID 747577Notes

Reaction equation

HRID 747577 reaction equation
[Br:1][C:2]1[S:6][C:5]([CH:7]([NH2:9])[CH3:8])=[CH:4][CH:3]=1.[CH3:10][O:11][C:12]([C:14]1[S:15][C:16]([C:19](O)=[O:20])=[CH:17][CH:18]=1)=[O:13]>>[CH3:10][O:11][C:12]([C:14]1[S:15][C:16]([C:19](=[O:20])[NH:9][CH:7]([C:5]2[S:6][C:2]([Br:1])=[CH:3][CH:4]=2)[CH3:8])=[CH:17][CH:18]=1)=[O:13]

Participants

3

Reactant 2

HCID 8183525-(Methoxycarbonyl)thiophene-2-carboxylic acidHCID 43593961-(5-Bromothiophen-2-yl)ethan-1-amine

Product 1

HCID 692923405-[1-(5-Bromo-thiophen-2-yl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester

Procedure

The title compound was prepared in an analogous manner to that described in example 1, step 1 from 1-(5-bromo-thiophen-2-yl)-ethylamine and thiophene-2,5-dicarboxylic acid monomethyl ester.

Sources & evidence

ORD record
ord-403d778aa425413482b07f6a84b59747
Source dataset
uspto-grants-2008_07
Patent number
US07396944B2

Reaction notes

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