反应详情

To 1 g of (2-amino-5-chlorophenyl)(3-methoxyphenyl)methanol dissolved in 6 ml of pyridine are added, at room temperature, 1.08 g of 3,4-dimethoxybenzenesulfonyl chloride. After 18 hours, the reaction medium is taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a column of silica gel, eluting with dichloromethane to give 1.65 g of the expected product.

1. additionare added, at room temperature
2. washwashed with water
3. dry with materialThe organic phase is dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe residue is chromatographed on a column of silica gel
6. washeluting with dichloromethane