2-Bromoacetamide → N2-{4-chloro-2-[hydroxy(3-methoxyphenyl)methyl]phenyl}-N2-[(3,4-dimethoxyphenyl)sulfonyl]glycinamide

Participants

Reaction Steps

To 0.7 g of N-{4-chloro-2-[(3-methoxyphenyl)(hydroxy)methyl]phenyl}-3,4-dimethoxybenzenesulfonamide dissolved in 5 ml of THF are added, at room temperature, 0.2 g of potassium tert-butoxide and 0.25 g of 2-bromoacetamide. After 48 hours at 20° C., the reaction medium is concentrated, taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a column of silica gel, eluting with dichloromethane to give 0.4 g of the expected product.

Provenance & Evidence