反应详情

To 0.7 g of N-{4-chloro-2-[(3-methoxyphenyl)(hydroxy)methyl]phenyl}-3,4-dimethoxybenzenesulfonamide dissolved in 5 ml of THF are added, at room temperature, 0.2 g of potassium tert-butoxide and 0.25 g of 2-bromoacetamide. After 48 hours at 20° C., the reaction medium is concentrated, taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a column of silica gel, eluting with dichloromethane to give 0.4 g of the expected product.

1. additionare added, at room temperature
2. concentrationthe reaction medium is concentrated
3. washwashed with water
4. dry with materialThe organic phase is dried over anhydrous sodium sulfate
5. concentrationconcentrated
6. customThe residue is chromatographed on a column of silica gel
7. washeluting with dichloromethane