反应详情

2.16 g (13.1 mmol) of ethyl 4-aminobenzoate was dissolved in 20 ml of benzene. 2.97 g (13.0 mmol) of 1,5-dibromopentane and 4.53 ml (26.0 mmol) of diisopropylethylamine were added to the solution, and they were heated under reflux for 48 hours. The reaction liquid was diluted with water. After the extraction with ethyl acetate, the organic layer was washed with water and then with saturated aqueous NaCl solution, and dried over anhydrous magnesium sulfate. The solvent was evaporated to obtain the crude title compound.

1. temperaturewere heated
2. temperatureunder reflux for 48 hours
3. customThe reaction liquid
4. extractionAfter the extraction with ethyl acetate
5. washthe organic layer was washed with water
6. dry with materialwith saturated aqueous NaCl solution, and dried over anhydrous magnesium sulfate
7. customThe solvent was evaporated