Sodium Hydroxide → HCID 17788839, compound

HRID 747683Notes

Reaction equation

HRID 747683 reaction equation
C[O:2][C:3]([C:5]1[CH:25]=[CH:24][C:8]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]2)=[O:10])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO.C1COCC1>[C:3]([C:5]1[CH:6]=[CH:7][C:8]([C:9]([N:11]2[CH2:12][CH2:13][N:14]([C:17]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:18])[CH2:15][CH2:16]2)=[O:10])=[CH:24][CH:25]=1)([OH:4])=[O:2]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 17789205t-Butyl 4-(4-methoxycarbonylbenzoyl)piperazine-1-carboxylate

Product 1

HCID 17788839HCID 17788839, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

7.08 g (20.3 mmol) of t-butyl 4-(4-methoxycarbonylbenzoyl)piperazine-1-carboxylate was stirred in 40 ml of methanol and 40 ml of THF. 51 ml (51 mmol) of 1 N aqueous sodium hydroxide solution was added to the resultant solution, and they were stirred at 80° C. for 20 minutes. The reaction liquid was evaporated under reduced pressure and 1 N hydrochloric acid was added to the residue. After the extraction with ethyl acetate followed with the treatment in an ordinary manner, the title compound was obtained.

Workup

  1. customThe reaction liquid
  2. customwas evaporated under reduced pressure and 1 N hydrochloric acid
  3. additionwas added to the residue
  4. extractionAfter the extraction with ethyl acetate

Sources & evidence

ORD record
ord-538a25aaa30649ca99c1da90104cfd85
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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