反应详情

温度

80 °C

7.08 g (20.3 mmol) of t-butyl 4-(4-methoxycarbonylbenzoyl)piperazine-1-carboxylate was stirred in 40 ml of methanol and 40 ml of THF. 51 ml (51 mmol) of 1 N aqueous sodium hydroxide solution was added to the resultant solution, and they were stirred at 80° C. for 20 minutes. The reaction liquid was evaporated under reduced pressure and 1 N hydrochloric acid was added to the residue. After the extraction with ethyl acetate followed with the treatment in an ordinary manner, the title compound was obtained.

1. customThe reaction liquid
2. customwas evaporated under reduced pressure and 1 N hydrochloric acid
3. additionwas added to the residue
4. extractionAfter the extraction with ethyl acetate