HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 68831095, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(2-Aminoethoxy)benzonitrile | HCID 10909877 | — |
| Reactant | HCID 17788839 | HCID 17788839 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 68831095 | HCID 68831095 | — |
Reaction Steps
1.60 g (4.8 mmol) of t-butyl 4-(4-carboxybenzoyl)piperazine-1-carboxylate, 1.58 g (8.0 mmol) of 3-(2-aminoethoxy)benzonitrile, 1.67 ml (12 mmol) of triethylamine, 650 mg (4.8 mmol) of 1-hydroxybenzotriazole and 920 mg (4.8 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were stirred in 20 ml of dimethylformamide at room temperature overnight. After the treatment with ethyl acetate as the extractant in an ordinary manner, the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07396844B1 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-5096a143cd18407da5e988b1de0e0e07 |
| Source note | uspto-grants-2008_07 |