反应详情

1.60 g (4.8 mmol) of t-butyl 4-(4-carboxybenzoyl)piperazine-1-carboxylate, 1.58 g (8.0 mmol) of 3-(2-aminoethoxy)benzonitrile, 1.67 ml (12 mmol) of triethylamine, 650 mg (4.8 mmol) of 1-hydroxybenzotriazole and 920 mg (4.8 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride were stirred in 20 ml of dimethylformamide at room temperature overnight. After the treatment with ethyl acetate as the extractant in an ordinary manner, the title compound was obtained.