Hydrochloric Acid → 4-(1H-Imidazol-2-yl)benzoic acid--hydrogen chloride (1/1)

HRID 747700Notes

Reaction equation

HRID 747700 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12]CC)=[O:11])=[CH:8][CH:7]=1.[ClH:17]>>[ClH:17].[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[CH:8][C:9]([C:10]([OH:12])=[O:11])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 17788902ethyl 4-(1H-imidazol-2-yl)benzoate

Product 1

HCID 688297154-(1H-Imidazol-2-yl)benzoic acid--hydrogen chloride (1/1)

Procedure

160 mg (0.74 mmol) of ethyl 4-(2-1H-imidazolyl)benzoate was heated under reflux in 4 ml of hydrochloric acid and 8 ml of acetic acid Three hours after, the solvent was evaporated to obtain the title compound.

Workup

  1. custom8 ml of acetic acid Three hours after, the solvent was evaporated

Sources & evidence

ORD record
ord-9234bcfd59ba4ed48ab75bdae05a0c06
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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