Sodium Hydroxide → 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid

HRID 747773Notes

Reaction equation

HRID 747773 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:16]=[CH:17][C:18]([C:19]([OH:21])=[O:20])=[CH:24][CH:25]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 11783050ethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoate

Product 1

HCID 27946494-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

847 mg (2.43 mmol) of ethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoate was dissolved in 50 ml of ethanol, and 5 ml of 1 N sodium hydroxide was added thereto, and they were stirred for 3 days. The reaction solution was concentrated and treated in an ordinary manner with ethyl acetate as the extractant to obtain the title compound.

Workup

  1. concentrationThe reaction solution was concentrated
  2. additiontreated in an ordinary manner with ethyl acetate as the extractant

Sources & evidence

ORD record
ord-c8232475ad78417ba480eb76be01816d
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

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