Sodium Hydroxide → 4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}benzoic acid

Participants

Reaction Steps

847 mg (2.43 mmol) of ethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoate was dissolved in 50 ml of ethanol, and 5 ml of 1 N sodium hydroxide was added thereto, and they were stirred for 3 days. The reaction solution was concentrated and treated in an ordinary manner with ethyl acetate as the extractant to obtain the title compound.

Provenance & Evidence