HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(Pyridine-4-yl)-piperidine-4-carboxylate chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 1-(Pyridin-4-yl)piperidine-4-carboxylic acid hydrochloride | HCID 16217269 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Pyridine-4-yl)-piperidine-4-carboxylate chloride | HCID 17789082 | — |
Reaction Steps
7 g (34 mmol) of 1-(pyridine-4-yl)-piperidine-4-carboxylate hydrochloride was stirred in 340 ml of dichloromethane, and 1 ml of dimethylformamide and 10.4 ml (109 mmol) of oxalyl dichloride were added thereto and stirred at room temperature for 1 hour. The solvent was distilled off, and the residue was dried with a vacuum pump to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07396844B1 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-2197a7a9cfe3418495ac5a2a708a9c04 |
| Source note | uspto-grants-2008_07 |