反应详情

2.1 g (16 mmol) of aluminum chloride and 2.4 g (12 mmol) of 4-chlorocarbonyl benzoic acid monomethyl ester were stirred in 15 ml of dichloromethane under stirring under cooling with ice. 1.0 g (9.3 mmol) of anisole was added to the resultant mixture. Two hours after, the temperature was elevated to room temperature, and the mixture was stirred overnight. After the treatment with dichloromethane as the extractant in an ordinary manner, the solvent was distilled off. The residue was purified by the silica gel column chromatography to obtain the title compound.

1. temperatureunder cooling with ice
2. customTwo hours
3. customwas elevated to room temperature
4. stirringthe mixture was stirred overnight
5. distillationAfter the treatment with dichloromethane as the extractant in an ordinary manner, the solvent was distilled off
6. customThe residue was purified by the silica gel column chromatography