HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[2-(3-cyanophenoxy)ethyl]-3-(E)-(4-chlorophenyl)acrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Propenoic acid, 3-(4-chlorophenyl)- | HCID 15371 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 3-(2-Aminoethoxy)benzonitrile hydrochloride | HCID 22645198 | — |
| Product | N-[2-(3-cyanophenoxy)ethyl]-3-(E)-(4-chlorophenyl)acrylamide | HCID 17788960 | — |
Reaction Steps
109 mg (0.55 mmol) of 3-(2-aminoethoxy)benzonitrile hydrochloride, 85 mg (0.55 mmol) of 1-hydroxybenzotriazole (hydrate), 105 mg (0.55 mmol) of 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride, 61 mg (0.6 mmol) of triethylamine, and 100 mg (0.55 mmol) of p-chloro-cinnamic acid were used, and the title compound was obtained in the same manner as in step 1 in Example 211.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07396844B1 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-b1619756e4a14decb6fa2c275ebb0070 |
| Source note | uspto-grants-2008_07 |