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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 747793Generated: October 30, 2026

Methyl 6-pyrrolidinonicotinate → 6-(Pyrrolidin-1-yl)nicotinic acid

https://huagongshe.com/reaction/747793

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 6-pyrrolidinonicotinateHCID 2794748—
SolventHydrochloric AcidHCID 313—
Product6-(Pyrrolidin-1-yl)nicotinic acidHCID 738055—

Reaction Conditions

Temperature40 °C

Reaction Steps

1.0 g (4.85 mol) of methyl 6-(pyrrolidine-1-yl)nicotinoate was dissolved in 10 ml of conc. hydrochloric acid and stirred at 40° C. overnight. The solvent was distilled off whereby the hydrochloride of the title compound was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07396844B1
Source datasetuspto-grants-2008_07
ORD IDord-55c46c1b6dc24d8aa997a33dcc511499
Source noteuspto-grants-2008_07