Methyl 6-pyrrolidinonicotinate → 6-(Pyrrolidin-1-yl)nicotinic acid

HRID 747793Notes

Reaction equation

HRID 747793 reaction equation
[N:1]1([C:6]2[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][N:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([C:6]2[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][N:7]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 1

HCID 2794748Methyl 6-pyrrolidinonicotinate

Product 1

HCID 7380556-(Pyrrolidin-1-yl)nicotinic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
40 °C

Procedure

1.0 g (4.85 mol) of methyl 6-(pyrrolidine-1-yl)nicotinoate was dissolved in 10 ml of conc. hydrochloric acid and stirred at 40° C. overnight. The solvent was distilled off whereby the hydrochloride of the title compound was obtained.

Workup

  1. distillationThe solvent was distilled off whereby the hydrochloride of the title compound
  2. customwas obtained

Sources & evidence

ORD record
ord-55c46c1b6dc24d8aa997a33dcc511499
Source dataset
uspto-grants-2008_07
Patent number
US07396844B1

Reaction notes

Loading…