Hydrochloric Acid → Oxycodone

HRID 747805Notes

Reaction equation

HRID 747805 reaction equation
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:22][CH3:23])=[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@:18]2([OH:21])[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15].Cl.C(=O)([O-])[O-].[Na+].[Na+].Cl.C(Cl)Cl>O>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3[CH:8]=[CH:9][C:10]([O:22][CH3:23])=[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@:18]2([OH:21])[C@:5]5([C:6]=34)[CH2:4][CH2:3]1)=[O:15]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 10340Sodium CarbonateHCID 5462350Oxycodone Hydrochloride

Product 1

HCID 5284603Oxycodone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The free base of oxycodone was prepared from its hydrochloride salt by the following method: Oxycodone hydrochloride was dissolved in water and sodium carbonate was added in the amount required to neutralize hydrochloric acid. Methylene chloride was added in order to extract the formed oxycodone free base. The obtained organic layer was dried over sodium sulfate and methylene chloride was evaporated using rotary evaporator. The obtained oxycodone free base was purified by crystallization.

Workup

  1. extractionto extract the formed oxycodone free base
  2. dry with materialThe obtained organic layer was dried over sodium sulfate and methylene chloride
  3. customwas evaporated
  4. customevaporator
  5. customThe obtained oxycodone free base was purified by crystallization

Sources & evidence

ORD record
ord-48fd9e4b54fb45c3ac19f0db82ed59db
Source dataset
uspto-grants-2008_07
Patent number
US07399488B2

Reaction notes

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