Benzyl 4-benzyl-3-oxopiperazine-1-carboxylate → 1-Benzylpiperazin-2-one

HRID 747841Notes

Reaction equation

HRID 747841 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10][C:9]1=[O:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][C:9]1=[O:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 59750509Benzyl 4-benzyl-3-oxopiperazine-1-carboxylate

Product 1

HCID 15143031-Benzylpiperazin-2-one

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of benzyl 4-benzyl-3-oxopiperazine-1-carboxylate (4.7 g, 14.5 mmol) and 10% Pd/C (0.47 g) in ethanol (150 mL) was stirred under an atmosphere of hydrogen (1 atm) at room temperature overnight. The product mixture was filtered through a pad of Celite, and concentrated under vacuum to provide 1-benzylpiperazin-2-one.

Workup

  1. filtrationThe product mixture was filtered through a pad of Celite
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-4a1ffa1f52fa4eb2bbb730eae986d1e3
Source dataset
uspto-grants-2008_07
Patent number
US07399763B2

Reaction notes

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