Diethylamine → HCID 59750616, compound

HRID 747878Notes

Reaction equation

Cl[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[C:20]([C:21]3[C:22]([O:29][CH3:30])=[N:23][C:24]([O:27][CH3:28])=[N:25][CH:26]=3)=[C:19]([CH3:31])[C:18]3[C:13](=[CH:14][C:15]([O:32]COCC[Si](C)(C)C)=[CH:16][CH:17]=3)[O:12]2)=[CH:7][CH:6]=1.[CH2:41]([NH:43][CH2:44][CH3:45])[CH3:42]>>[CH2:41]([N:43]([CH2:44][CH3:45])[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]2[C:20]([C:21]3[C:22]([O:29][CH3:30])=[N:23][C:24]([O:27][CH3:28])=[N:25][CH:26]=3)=[C:19]([CH3:31])[C:18]3[C:13](=[CH:14][C:15]([OH:32])=[CH:16][CH:17]=3)[O:12]2)=[CH:9][CH:10]=1)[CH3:42]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 11671495HCID 11671495, compound

Product 1

HCID 59750616HCID 59750616, compound

Procedure

The title product was prepared as a white solid according to the procedure described in Example 34 using 5-[2-[4-(2-Chloro-ethoxy)-phenyl]-4-methyl-7-(2-trimethylsilanyl-ethoxymethoxy)-2H-chromen-3-yl]-2,4-dimethoxy-pyrimidine and diethyl amine as the starting material.

Sources & evidence

ORD record: ord-2246985680ef417ab789c18904d953dd
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07399767B2

Reaction notes

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