Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate → 2-Methyl-6-[3-(5-methyl-2-phenyloxazol-4-ylmethoxy)cyclohexyloxymethyl]benzoic Acid

HRID 748027Notes

Reaction equation

HRID 748027 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([O:8][CH2:9][C:10]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:11]=2[C:12]([O:14]C)=[O:13])[CH2:3]1.[C:21]1([C:27]2[O:28][C:29]([CH3:34])=[C:30]([CH2:32]I)[N:31]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:10]([CH2:9][O:8][CH:4]2[CH2:5][CH2:6][CH2:7][CH:2]([O:1][CH2:32][C:30]3[N:31]=[C:27]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[O:28][C:29]=3[CH3:34])[CH2:3]2)[C:11]=1[C:12]([OH:14])=[O:13]

Participants

3

Reactant 2

HCID 21980299Methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoateHCID 224936584-(Iodomethyl)-5-methyl-2-phenyl-1,3-oxazole

Product 1

HCID 224936602-Methyl-6-[3-(5-methyl-2-phenyloxazol-4-ylmethoxy)cyclohexyloxymethyl]benzoic Acid

Procedure

Using methyl 2-(3-hydroxycyclohexyloxymethyl)-6-methylbenzoate and 2-phenyl-4-iodomethyl-5-methyloxazole as starting materials in the procedure of Example XXXI, gave the product 69 of molecular weight 435.52 (C26H29NO5), MS(ESI): 436.32 (M+H+).

Sources & evidence

ORD record
ord-2815bd93dea64c369f2b66cfd2d3916c
Source dataset
uspto-grants-2008_07
Patent number
US07399777B2

Reaction notes

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